| 產(chǎn)品編號 | bsm-30093M-PE |
| 英文名稱(chēng) | Mouse Anti-human CD4/PE Conjugated antibody |
| 中文名稱(chēng) | PE標記的小鼠抗人CD4單克隆抗體 |
| 別 名 | LHR; BA-1; CD 44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HSA; HUTCH-I; HUTCH1; Hyaluronate receptor; MDU2; MDU3; MIC4; MUTCH1; PGP-1; PGP1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; CD44 antigen isoform 1 precursor. |
| 規格價(jià)格 | 25T/260元 購買(mǎi) 50T/420元 購買(mǎi) 100T/680元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 25T 50T 100T |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 細胞表面分子 t-淋巴細胞 |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號 | HIT4a |
| 交叉反應 | |
| 產(chǎn)品應用 | Flow-Cyt=10ul/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD4 |
| 亞 型 | Mouse IgG2b |
| 純化方法 | affinity purified by Protein G |
| 儲 存 液 | 0.01M PBS, 0.5%BSA, 0.03% Proclin300 |
| 保存條件 | Store at 2-8℃. Protect from light. Avoid freezing. |
| 產(chǎn)品介紹 |
background: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]. Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Subunit: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. Post-translational modifications: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links:
Entrez Gene: 920 Human SwissProt: P01730 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 此抗體可識別55KDⅠ型單鏈穿膜糖蛋白。 CD4分子是存在于大多數輔助/誘導T細胞表面的59kDa的糖蛋白。正常淋巴組織中CD4的表達數量多于CD8，此抗體主要用于標記輔助/誘導T細胞，與CD8單抗聯(lián)合使用對外周血淋巴細胞分型。 CD4抗原是HLA-II類(lèi)分子和人類(lèi)免疫缺陷病毒(HIV)-愛(ài)滋病的受體，在35-50%外周血淋巴細胞-輔助和誘導T細胞(Th/Ti)和70-80%人胸腺細胞上表達，在人的單核細胞表面也有低密度的表達。 CD4抗原有膜結合型和可溶性?xún)煞N形式。Th/Ti可輔助Ig產(chǎn)生和T細胞毒T細胞的作用。 |
