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    Rabbit Anti-TIP120A/AP Conjugated antibody (bs-19935R-AP)
    訂購熱線(xiàn):400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術(shù)支持:techsupport@bioss.com.cn
    說(shuō) 明 書(shū): 100ul  
    100ul/2980.00元
    大包裝/詢(xún)價(jià)
    產(chǎn)品編號 bs-19935R-AP
    英文名稱(chēng) Rabbit Anti-TIP120A/AP Conjugated antibody
    中文名稱(chēng) 堿性磷酸酶(AP)標記的TBP相互作用蛋白TIP120A抗體
    別    名 CAND 1; Cand1; CAND1_HUMAN; Cullin associated and neddylation dissociated 1; Cullin associated and neddylation dissociated protein 1; Cullin associated NEDD8 dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; Cullin-associated NEDD8-dissociated protein 1; DKFZP434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; p120 CAND1; TATA binding protein interacting protein 120A; TBP interacting protein; TBP interacting protein of 120 kDa A; TBP Interacting Protein TIP120A; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TIP120; TIP120 protein.  
    規格價(jià)格 100ul/2980元 購買(mǎi)        大包裝/詢(xún)價(jià)
    說(shuō) 明 書(shū) 100ul  
    研究領(lǐng)域 細胞生物  表觀(guān)遺傳學(xué)  泛素  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    交叉反應 Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Sheep, )
    產(chǎn)品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 136kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human TIP120A
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產(chǎn)品介紹 Function:
    Enhances transcription from various types of promoters (By similarity). Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins.

    Subunit:
    Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins.

    Subcellular Location:
    Cytoplasm Nucleus.

    Similarity:
    Belongs to the CAND family.
    Contains 27 HEAT repeats.

    Database links:

    Entrez Gene: 452060 Chimpanzee

    Entrez Gene: 538086 Cow

    Entrez Gene: 55832 Human

    Entrez Gene: 71902 Mouse

    Entrez Gene: 100173509 Orangutan

    Entrez Gene: 117152 Rat

    Omim: 607727 Human

    SwissProt: A7MBJ5 Cow

    SwissProt: Q86VP6 Human

    SwissProt: Q6ZQ38 Mouse

    SwissProt: Q5R6L5 Orangutan

    SwissProt: P97536 Rat

    Unigene: 546407 Human

    Unigene: 203965 Mouse

    Unigene: 32934 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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