| 產(chǎn)品編號 |
bs-23056R-BF488 |
| 英文名稱(chēng) |
Rabbit Anti-TIMM8B/BF488 Conjugated antibody
|
| 中文名稱(chēng) |
BF488標記的線(xiàn)粒體內膜轉位酶8B |
| 別 名 |
DDP2; Deafness dystonia protein 2; FLJ21744; MGC102866; MGC117373; Mitochondrial import inner membrane translocase subunit Tim8 B; Small zinc finger like protein DDP2; TIM8B; ranslocase of inner mitochondrial membrane 8 homolog B (yeast); Translocase of inner mitochondrial membrane 8 homolog b; |
| 規格價(jià)格 |
100ul/2980元
購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 研究領(lǐng)域 |
腫瘤 細胞生物 線(xiàn)粒體 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類(lèi)型 |
Polyclonal |
| 交叉反應 |
(predicted: Human, Mouse, Rat, )
|
| 產(chǎn)品應用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
9kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human TIMM8B |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]
Function:
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
Subunit:
Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).
Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Tissue Specificity:
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
Similarity:
Belongs to the small Tim family.
Database links:
Entrez Gene: 26521 Human
Entrez Gene: 30057 Mouse
Entrez Gene: 64372 Rat
Omim: 606659 Human
SwissProt: Q9Y5J9 Human
SwissProt: P62077 Mouse
SwissProt: P62078 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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