| 產(chǎn)品編號 |
bs-17685R-PE-Cy5.5 |
| 英文名稱(chēng) |
Rabbit Anti-SPRED1/PE-Cy5.5 Conjugated antibody
|
| 中文名稱(chēng) |
PE-Cy5.5標記的SPRED1蛋白抗體 |
| 別 名 |
EVH1 domain-containing protein 1;
EVH1/Sprouty domain containing protein;
FLJ33903;
hSpred 1;
hSpred1;
NFLS;
SPRE1_HUMAN;
SPRED 1;
Spred-1;
spred1;
Sprouty related EVH1 domain containing 1;
Sprouty related protein 1 with EVH 1 domain;
Sprouty-related;
Suppressor of Ras/MAPK activation. |
| 規格價(jià)格 |
100ul/2980元
購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 研究領(lǐng)域 |
腫瘤 細胞生物 信號轉導 激酶和磷酸酶 G蛋白信號 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類(lèi)型 |
Polyclonal |
| 交叉反應 |
(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
|
| 產(chǎn)品應用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
50kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human SPRED1 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow.
Subcellular Location:
Cell membrane. Membrane > caveola. Nucleus. Localized in cholesterol-rich membrane raft/caveola fractions.
Tissue Specificity:
Weakly expressed in embryonic cell line (HEK-293).
Post-translational modifications:
Phosphorylated on tyrosine.
DISEASE:
Defects in SPRED1 are the cause of Legius syndrome (LEGIUSS) [MIM:611431]. It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity.
Similarity:
Contains 1 KBD domain.
Contains 1 SPR (sprouty) domain.
Contains 1 WH1 domain.
Database links:
Entrez Gene: 161742 Human
Entrez Gene: 114715 Mouse
Entrez Gene: 296072 Rat
Omim: 609291 Human
SwissProt: Q7Z699 Human
SwissProt: Q924S8 Mouse
Unigene: 525781 Human
Unigene: 245890 Mouse
Unigene: 392720 Mouse
Unigene: 392726 Mouse
Unigene: 397626 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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