| 產(chǎn)品編號 |
bs-17214R-PE |
| 英文名稱(chēng) |
Rabbit Anti-RCAD/PE Conjugated antibody
|
| 中文名稱(chēng) |
PE標記的RCAD蛋白抗體 |
| 別 名 |
K0776;
E3 UFM1-protein ligase 1;
KIAA0776;
LZAP-binding protein;
Maxer;
NLBP;
RCAD;
UFL1;
UFL1_HUMAN. |
| 規格價(jià)格 |
100ul/2980元
購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 研究領(lǐng)域 |
細胞生物 免疫學(xué) 泛素 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類(lèi)型 |
Polyclonal |
| 交叉反應 |
(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
|
| 產(chǎn)品應用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
89kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human RCAD |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3.
Subcellular Location:
Endoplasmic reticulum. Cytoplasm. In cytoplasm colocalizes with CDK5RAP3.
Tissue Specificity:
Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such HepG2, Hep3B, HLE and PLC.
Post-translational modifications:
Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.
Similarity:
Belongs to the UFL1 family.
Database links:
Entrez Gene: 23376 Human
Entrez Gene: 67490 Mouse
Entrez Gene: 313115 Rat
Omim: 613372 Human
SwissProt: O94874 Human
SwissProt: Q8CCJ3 Mouse
SwissProt: B2GV24 Rat
Unigene: 149367 Human
Unigene: 226295 Mouse
Unigene: 12784 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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