<strike id="fvzf9"><input id="fvzf9"><form id="fvzf9"></form></input></strike>
    <strike id="fvzf9"><blockquote id="fvzf9"></blockquote></strike>
  1. 
    
  2. <label id="fvzf9"><optgroup id="fvzf9"></optgroup></label>

    <span id="fvzf9"><input id="fvzf9"></input></span>

  3. 掃碼關(guān)注公眾號           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
      
    客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
    亚洲乱色伦图片区小说_產(chǎn)品中心-北京博奧森生物技術(shù)有限公司
    首頁(yè) > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
    Rabbit Anti-UBR5/PE-Cy3 Conjugated antibody (bs-13052R-PE-Cy3)
    訂購熱線(xiàn):400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術(shù)支持:techsupport@bioss.com.cn
    說(shuō) 明 書(shū): 100ul  
    100ul/2980.00元
    大包裝/詢(xún)價(jià)
    產(chǎn)品編號 bs-13052R-PE-Cy3
    英文名稱(chēng) Rabbit Anti-UBR5/PE-Cy3 Conjugated antibody
    中文名稱(chēng) PE-Cy3標記的E3泛素蛋白連接酶EDD抗體
    別    名 4432411E13Rik; AW549941; C77315; D030042K14; DD5; E3 identified by differential display; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase UBR5; EDD 1; EDD; EDD1; FLJ11310; HECT domain-containing 1; hHYD; HYD; Hyperplastic discs protein homolog; KIAA0896; MGC57263; mKIAA0896; Progestin induced protein; Progestin-induced protein; Rat100; Ubiquitin protein ligase; Ubiquitin protein ligase E3 component n recognin 5; UBR5; UBR5_HUMAN.  
    規格價(jià)格 100ul/2980元 購買(mǎi)        大包裝/詢(xún)價(jià)
    說(shuō) 明 書(shū) 100ul  
    研究領(lǐng)域 細胞生物  表觀(guān)遺傳學(xué)  泛素  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    交叉反應 Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Horse, Sheep, )
    產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 309kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human EDD
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產(chǎn)品介紹 background:
    EDD is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.

    Function:
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.

    Subunit:
    Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with DYRK2.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.

    Post-translational modifications:
    Phosphorylated upon DNA damage, probably by ATM or ATR.

    Similarity:
    Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    Contains 1 PABC domain.
    Contains 1 UBR-type zinc finger.

    Database links:

    Entrez Gene: 515582 Cow

    Entrez Gene: 51366 Human

    Entrez Gene: 70790 Mouse

    Entrez Gene: 100157625 Pig

    Entrez Gene: 117060 Rat

    Omim: 608413 Human

    SwissProt: O95071 Human

    SwissProt: Q80TP3 Mouse

    SwissProt: Q62671 Rat

    Unigene: 492445 Human

    Unigene: 476840 Mouse

    Unigene: 54812 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    版權所有 2004-2026 radiasunchina.com 北京博奧森生物技術(shù)有限公司
    通過(guò)國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號: 00124Q34771R2M/1100
    通過(guò)國際醫療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號: CQC24QY10047R0M/1100
    京ICP備05066980號-1         京公網(wǎng)安備110107000727號
    国产剧情演绎系列丝袜高跟|一级毛片av性爱黄色网站|欧美三级午夜理伦三级|国产av巨作情欲放纵|亚洲 欧美 中文 日韩aⅴ
    <strike id="fvzf9"><input id="fvzf9"><form id="fvzf9"></form></input></strike>
      <strike id="fvzf9"><blockquote id="fvzf9"></blockquote></strike>
    1. 
      
    2. <label id="fvzf9"><optgroup id="fvzf9"></optgroup></label>

      <span id="fvzf9"><input id="fvzf9"></input></span>