| 產(chǎn)品編號 | bs-12387R-APC |
| 英文名稱(chēng) | Rabbit Anti-KIF13B/APC Conjugated antibody |
| 中文名稱(chēng) | APC標記的驅動(dòng)蛋白家族蛋白13B抗體 |
| 別 名 | GAKIN; Guanylate kinase associated kinesin; KI13B_HUMAN; KIAA0639; KIF 13B; KIF13B; Kinesin 13B; Kinesin family member 13B; Kinesin like protein GAKIN; Kinesin like protein KIF13B; Kinesin-like protein GAKIN; Kinesin-like protein KIF13B; OTTHUMP00000225649. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細胞生物 神經(jīng)生物學(xué) 信號轉導 細胞骨架 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 203kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KIF13B |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: KIF13B is also known as Kinesin-like protein GAKIN or GAKIN and is a 1,826 amino acid protein that is widely expressed in tissues, with highest expression in brain and kidney. KIF13B is localized to the cytoplasm, as well as to the cytoskeleton, and is thought to be a microtubule-dependent motor protein which is able to bind to a variety of proteins in order to traffic them to various locations throughout the cell. KIF13B belongs to the kinesin-like protein family and possesses three domains typical of the kinesin-like protein family, namely an N-terminal motor domain with an ATP-binding motif, an FHA domain which is known to bind diverse cargos and a large stalk domain involved in protein-protein binding. Additionally, KIF13B has a microtubule-interacting sequence which is known as the CAP-Gly domain at its C-terminus. The CAP-Gly domain is highly conserved domain among eukaryotes, and in humans, defects in the CAP-Gly domain are implicated in many diseases affecting the trafficking of vesicles, neuromuscular junctions and lysosome proliferation. Function: May be involved in reorganization of the cortical cytoskeleton. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. Subunit: Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3. Subcellular Location: Cytoplasm; cytoskeleton. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the kinesin-like protein family. Contains 1 CAP-Gly domain. Contains 1 FHA domain. Contains 1 kinesin-motor domain. Database links: Entrez Gene: 23303 Human Entrez Gene: 16554 Mouse Omim: 607350 Human SwissProt: Q9NQT8 Human Unigene: 444767 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
