| 產(chǎn)品編號 |
bs-7723R-PE-Cy5 |
| 英文名稱(chēng) |
Rabbit Anti-REC8/PE-Cy5 Conjugated antibody
|
| 中文名稱(chēng) |
PE-Cy5標記的減數分裂重組蛋白家族REC8抗體 |
| 別 名 |
Cohesin Rec8p; Meiotic recombination protein REC8 homolog; Meiotic recombination protein REC8-like 1; rec8; REC8 homolog (yeast); REC8_HUMAN; REC8L; Rec8L1; Rec8p. |
| 規格價(jià)格 |
100ul/2980元
購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 研究領(lǐng)域 |
細胞生物 細胞周期蛋白 細胞分化 表觀(guān)遺傳學(xué) |
| 抗體來(lái)源 |
Rabbit |
| 克隆類(lèi)型 |
Polyclonal |
| 交叉反應 |
Human, Rat,
(predicted: Mouse, Dog, Pig, Horse, Rabbit, Guinea Pig, )
|
| 產(chǎn)品應用 |
Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
60kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human REC8 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
Function:
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).
Subunit:
Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51.
Subcellular Location:
Nucleus. Chromosome.
Tissue Specificity:
Expressed in testis and thymus.
Similarity:
Belongs to the rad21 family.
Database links:
Entrez Gene: 9985 Human
Entrez Gene: 56739 Mouse
Entrez Gene: 290227 Rat
Omim: 608193 Human
SwissProt: O95072 Human
SwissProt: Q8C5S7 Mouse
SwissProt: Q6AYJ4 Rat
Unigene: 419259 Human
Unigene: 23149 Mouse
Unigene: 108612 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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