| 產(chǎn)品編號 | bs-0664R-PE-Cy3 |
| 英文名稱(chēng) | Rabbit Anti-HMGB1/PE-Cy3 Conjugated antibody |
| 中文名稱(chēng) | PE-Cy3標記的高遷移率族蛋白B1抗體 |
| 別 名 | Amphoterin; High mobility group 1; High Mobility Group Box 1; High mobility group protein 1; High mobility group protein B1; HMG3; HMGB 1;HMGB-1; Hmgb1 protein; Nonhistone chromosomal protein HMG1; SBP 1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; HMGB1_HUMAN. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 轉錄調節因子 結合蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, (predicted: Mouse, Rat, Cow, ) |
| 產(chǎn)品應用 | Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HMGB1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models Function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Subunit: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Subcellular Location: Nucleus. Chromosome. Similarity: Belongs to the HMGB family. Contains 2 HMG box DNA-binding domains. Database links: Entrez Gene: 3146 Human Entrez Gene: 100862258 Mouse Entrez Gene: 15289 Mouse Omim: 163905 Human SwissProt: P09429 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 近來(lái)的研究表明稱(chēng)之為高遷移率族蛋白B-1（HMG-B1）的核內結構蛋白在核外表達時(shí)是一種有效的早期炎癥介質(zhì)。 高遷移性Ｂ１組蛋白（ＨＭＧＢ１）： 是一種核結合蛋白，在ＤＮＡ重組、修復、復制和基因轉錄中起作用。ＨＭＧＢ１也是巨噬細胞分泌的一種介質(zhì)。 此外，高遷移性Ｂ１組蛋白亦被受刺激的巨噬細胞或單核細胞主動(dòng)分泌。在這一主動(dòng)分泌過(guò)程中，HMGB1首先經(jīng)乙?；⒂珊藘绒D移至溶酶體內，繼而在A(yíng)TP和溶血磷脂膽堿兩種分泌信號指導下轉移至細胞外。由壞死細胞被動(dòng)釋放的HMGB1和炎癥細胞主動(dòng)分泌的HMGB1存在分子上的差異。胞外的HMGB1可作為細胞因子參與信號傳導，因為它既可識別Toll 樣受體（TLR）家族的一些成員，又能與識別晚期糖基化終末產(chǎn)物受體（RAGE）相作用。 HMGB1能啟動(dòng)炎癥反應，包括產(chǎn)生多種細胞因子、對某些干細胞產(chǎn)生趨化作用、誘導血管粘附分子、削弱腸上皮細胞的功能等。 |
