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    Rabbit Anti-Phospho-NMDAR1(Ser896)/PE-Cy3 Conjugated antibody (bs-3302R-PE-Cy3)
    訂購熱線(xiàn):400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術(shù)支持:techsupport@bioss.com.cn
    說(shuō) 明 書(shū): 100ul  
    100ul/2980.00元
    大包裝/詢(xún)價(jià)
    產(chǎn)品編號 bs-3302R-PE-Cy3
    英文名稱(chēng) Rabbit Anti-Phospho-NMDAR1(Ser896)/PE-Cy3 Conjugated antibody
    中文名稱(chēng) PE-Cy3標記的磷酸化離子型谷氨酸受體1抗體
    別    名 NMDAR1 C1 (phospho S896); p-NMDAR1 C1 (phospho S896); NMDAR1(Phospho-Ser896); NMDAR1(Phospho-S896); NMDAR1 C1 (phospho S896); p-NMDAR1(S896); p-NMDAR1(Ser896); NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN.  
    規格價(jià)格 100ul/2980元 購買(mǎi)        大包裝/詢(xún)價(jià)
    說(shuō) 明 書(shū) 100ul  
    產(chǎn)品類(lèi)型 磷酸化抗體 
    研究領(lǐng)域 細胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉導  轉錄調節因子  激酶和磷酸酶  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, )
    產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 103kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser896
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產(chǎn)品介紹 background:
    Neuronal Marker
    The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

    Function:
    NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

    Subunit:
    Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with MYZAP.

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

    Post-translational modifications:
    NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.

    DISEASE:
    Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

    Similarity:
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.

    Database links:

    Entrez Gene: 2902 Human

    Entrez Gene: 14810 Mouse

    Entrez Gene: 24408 Rat

    Omim: 138249 Human

    SwissProt: Q05586 Human

    SwissProt: P35438 Mouse

    SwissProt: P35439 Rat

    Unigene: 558334 Human

    Unigene: 278672 Mouse

    Unigene: 9840 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    神經(jīng)細胞標志物
    (NMDAR1)N-甲基-D-天門(mén)冬氨酸受體(NMDAR)是興奮性氨基酸受體亞型之一,是由NMDAR1與不同的NMDAR2亞基組成的異聚體。
    NMDAR1又稱(chēng)GluR1 (Glutamate Receptor 1)近年實(shí)驗研究發(fā)現,許多NMDAR拮抗藥均具有鎮痛活性,表明NMDAR在痛覺(jué)傳遞中具有重要作用,這為新型鎮痛藥的研究開(kāi)發(fā)提供了新的作用靶點(diǎn)。
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