| 產(chǎn)品編號 | bs-2423R-Cy5 |
| 英文名稱(chēng) | Rabbit Anti-DLK1/Cy5 Conjugated antibody |
| 中文名稱(chēng) | Cy5標記的穿膜蛋白DLK1抗體 |
| 別 名 | Adipocyte differentiation inhibitor protein; Brevideltin; Delta like 1 homolog; Delta like homolog; Delta like protein; Delta1; DLK 1; DLK; DLK-1; Dlk1; DLK1_HUMAN; FA 1; FA1; Fetal antigen 1; pG2; Preadipocyte factor 1; Pref 1; Pref; Pref1; Pref-1; Protein delta homolog 1; Secredeltin; ZOG; Delta1; PREF1. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 神經(jīng)生物學(xué) 信號轉導 干細胞 轉錄調節因子 結合蛋白 細胞表面分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Human, (predicted: Mouse, Rat, Pig, Rabbit, Sheep, ) |
| 產(chǎn)品應用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DLK1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]. Function: May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. Subunit: Monomer. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary and, to a lesser degree, in adult kidney, muscle, thymus and heart. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 6 EGF-like domains. Database links: Entrez Gene: 8788 Human Entrez Gene: 13386 Mouse Omim: 176290 Human SwissProt: P80370 Human SwissProt: Q09163 Mouse Unigene: 533717 Human Unigene: 157069 Mouse Unigene: 14547 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 穿膜蛋白DLK1又稱(chēng)肝癌相關(guān)基因，是表皮生長(cháng)因子(EGF)家族的成員之一,其結構特征為蛋白的細胞外區域擁有在結構及氨基酸序列上與表皮生長(cháng)因子高度同源的重復結構.DLK1可以抑制脂肪前體細胞向脂肪細胞分化,在正常神經(jīng)內分泌細胞及其腫瘤細胞中表達, DLK1在神經(jīng)內分泌軸中起著(zhù)調控細胞生長(cháng)分化的作用,同時(shí)DLK1在胚胎肝、造血干細胞及早期肌肉組織中均有表達。 |
