| 產(chǎn)品編號 | bs-1254R-Gold |
| 英文名稱(chēng) | Rabbit Anti-Apolipoprotein D/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標記的載脂蛋白D抗體 |
| 別 名 | Apolipoprotein D; APOD; APO D; APOD protein; APOD_HUMAN; Apolipoprotein D; Apo-D; ApoD. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 心血管 細胞生物 免疫學(xué) 神經(jīng)生物學(xué) Alzheimer's |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Rabbit, ) |
| 產(chǎn)品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APOD |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: Apolipoprotein D (APO D), a glycoprotein involved in the human plasma lipid transport system. It is a progesterone binding glycoprotein of 24,000 dalton monomer molecular size, is a constituent of high density lipoprotein in plasma. The function of apolipoprotein D in the metabolism of plasma lipoproteins is unclear but the observation that this protein forms complexes with lecithin: cholesterol acyltransferase has led to the suggestion that apolipoprotein D may be involved in cholesterol esterification and transport of substrates and products of the reaction. Apolipoprotein D is expressed in a range of normal tissues including axillary apocrine glands, adrenal cortex and corpus luteum. Peripheral nerves, pituitary, testis, cerebellum and renal tubes are also positive. APO D was first isolated in large quantity as GCDFP 24, the major protein component of most human breast cyst fluids. In recent studies, Apo D immunoreactivity has been shown to be an early indicator of prostate cancer and advanced primary prostate tumors. Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. Subunit: Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2. Subcellular Location: Secreted. Tissue Specificity: Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears. Post-translational modifications: N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor). Similarity: Belongs to the calycin superfamily. Lipocalin family. Database links: Entrez Gene: 347 Human Omim: 107740 Human SwissProt: P05090 Human Unigene: 522555 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 載脂蛋白D(apolipoprotein D,apoD)是一個(gè)糖蛋白,它最初是在人血漿的高密度脂蛋白中被分離出來(lái)的。apoD在結構上與其他類(lèi)型的載脂蛋白存在很大的差異,被歸入脂肪促成素家族。apoD可以與膽固醇、黃體酮、膽紅素等多種疏水性小分子結合。 apoD在多種脊索動(dòng)物的各類(lèi)組織中廣泛表達, 在脊椎動(dòng)物中重要的生理功能。最近的研究表明,apoD可以作為多種癌癥及神經(jīng)系統疾病的早期診斷標記, apoD是一個(gè)多配體、多功能的蛋白質(zhì). |
