| 產(chǎn)品編號 |
bs-41281P |
| 英文名稱(chēng) |
Recombinant SARS-Cov-2 Spike S1 protein
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| 中文名稱(chēng) |
重組SARS冠狀病毒2-S1蛋白 |
| 別 名 |
SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2; Recombinant SARS-Cov-2 Spike S1 protein 重組SARS冠狀病毒2 Spike S1蛋白; 新冠病毒S蛋白; 新冠S蛋白; 新冠S1蛋白; SARS-CoV-2 S1蛋白; |
| 克 隆 號 |
|
| 理論分子量 |
78 kDa |
| 檢測分子量 |
35 |
| 性 狀 |
Liquid |
| 濃 度 |
＞0.5 mg/ml |
| 物 種 |
SARS-Cov-2 |
| 序 列 |
16-685/1273 |
| 純 度 |
>95% as determined by SDS-PAGE |
| 純化方法 |
AC |
| 內毒素 |
Not analyzed |
| 表達系統 |
E.coli |
| 活性 |
Not tested |
| 標簽 |
Tag free |
| 緩 沖 液 |
Lyophilized from 0.22um filtered solution in 2X PBS (pH7.4). Normally 5% trehalose is added as protectant before lyophilization. |
| 保存條件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
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