| 產(chǎn)品編號 | V1202 |
| 英文名稱(chēng) | Human MPO Mouse mAb |
| 中文名稱(chēng) | 髓過(guò)氧化物酶單克隆抗體 |
| 別 名 | Myeloperoxidase; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN. |
| 克 隆 號 | 6A8 |
| 理論分子量 | 84 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 0.01M PBS(pH7.4) |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] SWISS: P05164 Gene ID: 4353 髓過(guò)氧化物酶MPO,作為一種白細胞酶,具有介導炎性反應、調節免疫應答等多種功能,并可參與疾病的發(fā)生發(fā)展過(guò)程。同時(shí),髓過(guò)氧化物酶基因存在基因多態(tài)性,也影響機體對疾病的易感性. 在正常淋巴組織中和各種髓樣細胞增生癥中，MPO均有較強表達，如：淋巴樣細胞、原核細胞、肥大細胞、漿細胞以及各種上皮源性腫瘤和肉瘤等。 髓過(guò)氧化物酶(myeloperoxidase,MPO),是一種血紅素蛋白，富含于中性粒細胞中,由粒細胞進(jìn)入循環(huán)之前在骨髓內合成并存儲于噬天青顆粒內。外界刺激可導致中性粒細胞聚集，從而釋放髓過(guò)氧化物酶。M |
