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    PCSK9 Mouse mAb (bsm-43105M)  
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    50ul/1180.00元
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    200ug(PBS only)/5600.00元
    大包裝/詢(xún)價(jià)

    產(chǎn)品編號 bsm-43105M
    英文名稱(chēng) PCSK9 Mouse mAb
    中文名稱(chēng) 神經(jīng)細胞凋亡調節轉化蛋白1/前蛋白轉化酶枯草溶菌素9單克隆抗體
    別    名 FH3; HCHOLA3; Hypercholesterolemia autosomal dominant 3; NARC 1; NARC-1; NARC1; Neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; PC 9; PC9; PCSK 9; PCSK9; PCSK9_HUMAN; Proprotein convertase 9; Proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; PSEC0052; Subtilisin/kexin like protease PC9; Subtilisin/kexin-like protease PC9.  神經(jīng)細胞凋亡調節轉化蛋白1/前蛋白轉化酶枯草溶菌素9
    抗體來(lái)源 Mouse
    克隆類(lèi)型 Monoclonal
    克 隆 號
    交叉反應 Human (predicted: Mouse,Rat)
    產(chǎn)品應用 WB=1:500-2000
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 57 kDa
    檢測分子量
    細胞定位 分泌型蛋白 
    性    狀 Liquid
    免 疫 原 Recombinant human PCSK9 protein: 31-692/692 
    亞    型
    純化方法 affinity purified by Protein A
    緩 沖 液 PBS (pH=7.4).
    保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.

    Function:
    The precursor protein but not the mature protein may form multimers.

    Subunit:
    The precursor protein but not the mature protein may form multimers.

    Subcellular Location:
    Secreted.

    Tissue Specificity:
    Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

    Post-translational modifications:
    The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.

    Similarity:
    Belongs to the peptidase S8 family. Contains 1 peptidase S8 domain.

    SWISS:
    Q8NBP7

    Gene ID:
    255738

    Database links:

    Entrez Gene: 255738 Human

    Entrez Gene: 100102 Mouse

    Entrez Gene: 298296 Rat

    Omim: 607786 Human

    SwissProt: Q8NBP7 Human

    SwissProt: Q80W65 Mouse

    SwissProt: P59996 Rat

    Unigene: 18844 Human

    Unigene: 133268 Mouse

    Unigene: 19195 Rat



    前蛋白轉化酶枯草溶菌素9(PCSK9)是近年來(lái)新發(fā)現的一種與調節脂質(zhì)代謝密切相關(guān)的基因,編碼前蛋白轉化酶NARC-1。Narc-1/pcsk9可通過(guò)調節細胞表面的低密度脂蛋白受體(LDLR)水平,參與脂質(zhì)代謝,從而在動(dòng)脈粥樣硬化性疾病的發(fā)生、發(fā)展中發(fā)揮重要作用。
    產(chǎn)品圖片
    Sample: Lane 1: Recombinant human PCSK9 protein, C-His (HEK293)(bs-43105P) Primary: Anti-PCSK9 (bsm-43105M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 57 kDa Observed band size: 67 kDa
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