| 產(chǎn)品編號 | bsm-33864M |
| 英文名稱(chēng) | FOLH1 Mouse mAb |
| 中文名稱(chēng) | 前列腺特異膜抗原單克隆抗體 |
| 別 名 | FOLH; PMSA; Cell growth inhibiting protein 27; FGCP; Folate hydrolase 1; folate hydrolase; Folate hydrolase prostate specific membrane antigen 1; FOLH 1; FOLH; Folylpoly gamma glutamate carboxypeptidase; GCP 2; GCP II; GCP2; GCPII; glutamate carboxylase II; Glutamate carboxypeptidase 2; glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; mGCP; N acetylated alpha linked acidic dipeptidase 1; N acetylated alpha linked acidic dipeptidase I; NAALAD 1; NAALAD1; NAALAdase; NAALADase I; prostate specific membrane antigen; PSM; pteroylpoly gamma glutamate carboxypeptidase; FOLH1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細胞表面分子 |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號 | |
| 交叉反應 | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應用 | IHC-P=1:100-500,IHC-F=1:400-800,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 84 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FOLH1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.
Subunit : Homodimer. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm. Tissue Specificity: Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. Similarity: Belongs to the peptidase M28 family. M28B subfamily. SWISS: Q04609 Gene ID: 2346 Database links: Entrez Gene: 2346 Human Omim: 600934 Human SwissProt: Q04609 Human Unigene: 654487 Human |
