| 產(chǎn)品編號 | bsk11002 |
| 英文名稱(chēng) | Human IL-2 ELISA Kit |
| 中文名稱(chēng) | 人白細胞介素2酶聯(lián)免疫試劑盒 |
| 別 名 | IL2, IL-2, TCGF, lymphokine, interleukin 2 |
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Specific References (2) | bsk11002 has been referenced in 2 publications.
[IF=17.521] Lizhen He. et al. Metabolic Reprogramming of NK Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy. Advanced Science. 2023 Jan;:2202519 ELISA ; Human.
[IF=10.273] Lai H et al. Selenium-containing ruthenium complex synergizes with natural killer cells to enhance immunotherapy against prostate cancer via activating TRAIL/FasL signaling. Biomaterials. 2019 Jul 24;219:119377. ELISA ; Human.
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| 種 屬 | Human |
| 線(xiàn)性范圍 | 7.81 - 500 pg/mL |
| 應用范圍 | S/P/CC |
| 檢測限 | 4 pg/mL |
| 適用樣品基質(zhì) | cell culture supernates, serum, and plasma. |
| 保存條件 | Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.). |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes. Human IL-2 (also known as T-cell growth factor) is produced by T-cells in response to antigenic or mitogenic stimulation. IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells promoting proliferation and maturation.IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. IL-2 is involved in treatment of cancers such as melanoma and renal cell cancer. It plays a key role in promoting the clonal expansion of antigen-specific T cells. In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types.
白介素-2(Interleukin-2,IL-2)是輔助型T淋巴細胞(TH)活化產(chǎn)生的細胞因子[1-2]。IL-2具有雙重調控免疫應變的能力,可有效誘導細胞免疫和體液免疫應答。 白介素（IL-2)的主要生理作用是刺激和維持T細胞的分化增殖。IL-2有關(guān)腫瘤的生物學(xué)活性包括：1.刺激自然殺傷(NK)細胞的增殖和活化，并增強其活性。2.誘導細胞毒性淋巴細胞，增強其溶細胞活性。3.誘導淋巴因子活化殺傷(LAK)細胞。LAK細胞具有廣譜的抗腫瘤活性，可以溶解多種腫瘤細胞。IL-2不僅是產(chǎn)生LAK細胞的必需淋巴因子，而且在它的存在下還能維持LAK細胞的增殖和長(cháng)期生長(cháng)，因此，在臨床抗腫瘤治療時(shí)往往把IL-2和LAK細胞同時(shí)給予，這就是惡性腫瘤的過(guò)繼免疫性治療(adoptiveimmunetherapy，AIT)。4.刺激腫瘤浸潤淋巴細胞(TIL)的增生并增強其活性。動(dòng)物實(shí)驗證明，TIL較LAK細胞的抗腫瘤活性高50～100倍。5.不僅能促進(jìn)T細胞增殖，且對細胞有促增殖和促分化作用。在腫瘤治療的動(dòng)物模型中已證明，當T細胞中介抗瘤反應強烈時(shí)，很低量的IL-2已足以激化抗瘤作用；但當T細胞中介的抗瘤反應很弱時(shí)，則需要很高劑量的IL-2。低劑量可以顯著(zhù)地刺激T細胞，而激活NK及LAK細胞則要求很大劑量。因IL-2不能直接抗癌，用藥目的是最大限度地興奮免疫機制，以加強抗癌作用。以前常用的IL-2和LAK細胞聯(lián)合應用治療惡性腫瘤，現已不再推薦，而代之以IL-2與腫瘤浸潤淋巴細胞(TIL)聯(lián)合療法。6.rhIL-11為177個(gè)氨基酸組成的活性蛋白質(zhì)。其編碼基因位于19號染色體長(cháng)臂13區。作用于巨核細胞系較晚期階段的巨核細胞水平，促進(jìn)巨核細胞的增殖及成熟，并促進(jìn)血小板的產(chǎn)生。IL-11雖無(wú)巨核細胞集落刺激因子(Meg-CSF)的活性，但有巨核細胞增殖因子的活性，與GM-CSF及IL-3協(xié)同作用，可使CFU-MegDNA量增多。 |
