| 產(chǎn)品編號 | bs-13227R |
| 英文名稱(chēng) | FUNDC1 Rabbit pAb |
| 中文名稱(chēng) | X三體綜合癥相關(guān)蛋白FUNDC1抗體 |
| 別 名 | FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN. |
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Specific References (1) | bs-13227R has been referenced in 1 publications.
[IF=4.011] Xu G et al. Fundc1?is?necessary?for?proper?body?axis?formation?during?embryogenesis?in zebrafish. Sci Rep.?2019 Dec 11;9(1):18910. WB ; grass carp&Human.
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| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 發(fā)育生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | Human,Mouse,Rat |
| 產(chǎn)品應用 | WB=1:300-800,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 17 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse FUNDC1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
FUNDC1 is a 155 amino acid protein belonging to the FUN14 family. The gene encoding FUNDC1 maps to human chromosome Xp11.3 and mouse chromosome X A1.2. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Subunit: Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP. Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy. Similarity: Belongs to the FUN14 family. SWISS: Q9DB70 Gene ID: 72018 Database links: Entrez Gene: 139341 Human Entrez Gene: Mouse Entrez Gene: 72018 Mouse Omim: 300871 Human SwissProt: Q8IVP5 Human SwissProt: Q9DB70 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Cerebellum tissue lysates
Lane 2: Mouse Heart tissue lysates
Lane 3: Human 293T cell lysates
Lane 4: Human MCF-7 cell lysates
Lane 5: Human A549 cell lysates
Primary: Anti-FUNDC1 (bs-13227R) at 1/800 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa
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