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    AZI1 Rabbit pAb (bs-12977R)  
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    產(chǎn)品編號 bs-12977R
    英文名稱(chēng) AZI1 Rabbit pAb
    中文名稱(chēng) 中心體蛋白AZI1抗體
    別    名 5 azacytidine induced 1; 5-azacytidine induced 1; 5-azacytidine-induced protein 1; AZ1; Azi; Azi1; AZI1_HUMAN; Centrosomal protein 131 kDa; Centrosomal protein of 131 kDa; Centrosomal protein of 131 kDa; Cep131; Cep131; KIAA1118; OTTMUSP00000004498; Pre-acrosome localization protein 1; RP23 37J21.1.  
    研究領(lǐng)域 細胞生物  細胞類(lèi)型標志物  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Rat (predicted: Human,Mouse,Pig,Sheep,Cow,Chicken,Horse)
    產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 122 kDa
    檢測分子量
    細胞定位 細胞漿 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human AZI1: 631-730/1083 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 AZI1 is a 1,083 amino acid protein that may play a role in spermatogenesis. AZI1 is most highly expressed in spinal cord, followed by testis, ovary, amygdala, cerebellum and thalamus. Low expression is present in other adult and fetal tissues and specific adult brain regions. AZl1 gene transcription begins in pachytene spermatocytes and expression of the gene is induced in cultivated fibroblasts on treatment with 5-azacytidine, which is known to lead to the demethylation of genomic DNA. The AZI1 gene is conserved in dog, cow, mouse, rat, chicken, and zebrafish, and exists as two alternatively spliced isoforms. AZI1 contains one IQ domain, and the gene that encodes it maps to human chromosome 17q25.3. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

    Function:
    May play a role in spermatogenesis.

    Subcellular Location:
    Cytoplasm > cytoskeleton > centrosome.

    Post-translational modifications:
    Phosphorylated upon DNA damage, probably by ATM or ATR.

    Similarity:
    Contains 1 IQ domain.

    SWISS:
    Q9UPN4

    Gene ID:
    22994

    Database links:

    Entrez Gene: 22994 Human

    Omim: 613479 Human

    SwissProt: Q9UPN4 Human

    Unigene: 514578 Human



    產(chǎn)品圖片
    Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AZI1) Polyclonal Antibody, Unconjugated (bs-12977R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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