| 產(chǎn)品編號 | bs-12413R |
| 英文名稱(chēng) | LTBP1 Rabbit pAb |
| 中文名稱(chēng) | 轉化生長(cháng)因子β1結合蛋白1抗體 |
| 別 名 | 9430031G15Rik; 9830146M04; Latent transforming growth factor beta binding protein 1; Latent-transforming growth factor beta-binding protein 1; Latent-transforming growth factor beta-binding protein, isoform 1L; Latent-transforming growth factor beta-binding protein, isoform 1S; LBT1S; LTBP-1; Ltbp1; LTBP1_HUMAN; MGC163161; TGF-beta1-BP-1; Tgfb; Transforming growth factor beta-1-binding protein 1; Transforming growth factor beta-1-masking protein large subunit. |
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Specific References (1) | bs-12413R has been referenced in 1 publications.
[IF=0] William J. Burlingham. et al. Extracellular Vesicle–associated GARP/TGFβ:LAP Mediates “Infectious” Allo-tolerance. TRANSPLANT DIRECT. 2023 Jun; 9(6): e1475 ELISA ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細胞生物 信號轉導 干細胞 生長(cháng)因子和激素 轉錄調節因子 細胞外基質(zhì) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | (predicted: Human,Mouse,Rat,Rabbit,Cow) |
| 產(chǎn)品應用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 184 kDa |
| 檢測分子量 | |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LTBP1: 221-320/1721 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Latent transforming growth factor-beta 1 binding protein 1 (LTBP-1), a heavy glycoprotein, is part of the platelet-derived TGF-beta 1 complex. LTBP-1 serves as an anchor for latent TGF-beta in the extracellular matrix and is a component of microfibrillar structures. Cleavage of LTBP results in LTBP-1, which may sequester latent TGF-beta in the extracellular matrix and regulate its activation. LTBP-1 mRNA is enriched in ovarian carcinoma tissues and highly expressed in serous and mucinous adenocarcinomas. Function: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Subunit: The large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1. Binds to FBN1 and FBN2. Interacts with ADAMTSL2. Subcellular Location: Secreted. Tissue Specificity: Isoform Long is found in fibroblasts. Post-translational modifications: Contains hydroxylated asparagine residues. Isoform Short N-terminus is blocked. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Similarity: Belongs to the LTBP family. Contains 18 EGF-like domains. Contains 4 TB (TGF-beta binding) domains. SWISS: Q14766 Gene ID: 4052 Database links: Entrez Gene: 4052 Human Entrez Gene: 268977 Mouse Omim: 150390 Human SwissProt: Q14766 Human SwissProt: Q8CG19 Mouse Unigene: 619315 Human Unigene: 269747 Mouse Unigene: 40942 Rat |
