| 產(chǎn)品編號 | bs-7606R |
| 英文名稱(chēng) | CYFIP2 Rabbit pAb |
| 中文名稱(chēng) | 細胞質(zhì)脆性X智力低下蛋白結合蛋白2抗體 |
| 別 名 | CYFP2; cytoplasmic FMR1 interacting protein 2; KIAA1168; p53 inducible protein; p53-inducible protein 121; PIR121; CYFP2_HUMAN. |
| 研究領(lǐng)域 | 細胞生物 神經(jīng)生物學(xué) 信號轉導 細胞凋亡 轉錄調節因子 t-淋巴細胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Chicken,Dog,Horse) |
| 產(chǎn)品應用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 148 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CYFIP2: 251-350/1273 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CYFIP2 is involved in T cell adhesion and p53 dependent induction of apoptosis. It does not bind RNA but is up regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis. There are 2 isoforms produced by alternative splicing. Function: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA Subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Subcellular Location: Cytoplasm. Cytoplasm, perinuclear region. Cell junction , synapse, synaptosome. Note: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. Tissue Specificity: Expressed in T-cells. Increased expression is observed in CD4+ T-lymphocytes from patients with multiple sclerosis (at protein level). Similarity: Belongs to the CYFIP family. SWISS: Q96F07 Gene ID: 26999 Database links: UniProtKB/Swiss-Prot: Q96F07.2 脆性X綜合癥，又稱(chēng)馬?。悹柧C合癥，是一種遺傳疾病。該綜合癥可以導致一系列的特征性癥狀，包括生理、智力、情緒、以及行為上的異常。癥狀的輕重各有不同。該疾病伴隨著(zhù)X染色體上一個(gè)簡(jiǎn)單的三核苷酸基因序列（CGG）的擴增。這種擴增導致了一種稱(chēng)為FMR-1的蛋白質(zhì)無(wú)法在病人體內表達，而該蛋白質(zhì)是神經(jīng)的正常發(fā)育必不可少的。 根據CGG重復序列的長(cháng)度，目前普遍認可將脆性X綜合癥分為四種類(lèi)型：正常人（含有19－31個(gè)CGG重復序列），前突變者（含有55－200個(gè)CGG重復序列），全突變者（含有200個(gè)以上的CGG重復序列），過(guò)渡型，又稱(chēng)“灰色區域型”（含有40－60個(gè)重復）。脆性X綜合征這是一種導致智力低下的遺傳疾病，是導致人群中智力低下的第二大病因——僅次于21三體綜合癥。 |
