| 產(chǎn)品編號 | bs-4292R |
| 英文名稱(chēng) | BPI Rabbit pAb |
| 中文名稱(chēng) | 殺菌/通透性增強蛋白抗體 |
| 別 名 | Neutrophil Bactericidal Protein BP30; Bactericidal permeability-increasing protein; Bactericidal/permeability increasing protein; BPI_HUMAN; CAP 57; CAP-57; BPI fold containing family D, member 1; BPIFD1. |
| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 細胞凋亡 細菌及病毒 t-淋巴細胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | (predicted: Human) |
| 產(chǎn)品應用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 細胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BPI: 141-240/487 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Subunit: Monomer. Homodimer; disulfide-linked. Subcellular Location: Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. Tissue Specificity: Restricted to cells of the myeloid series. Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. SWISS: P17213 Gene ID: 671 Database links: Entrez Gene: 671 Human Omim: 109195 Human SwissProt: P17213 Human Unigene: 529019 Human 殺菌／通透性增加蛋白(Bactericidal／permeability-increasing protein，BPI)是哺乳動(dòng)物中性粒細胞中存在的一種堿性蛋白，BPI能與革蘭氏陰性菌脂多糖結合，增加外膜對抗菌藥物的通透性，具有中和內毒素和殺滅細菌的生物學(xué)作用，在革蘭氏陰性菌感染的治療方面有良好的發(fā)展前景。 |
