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    MAS1 Rabbit pAb (bs-5925R)  
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    產(chǎn)品編號 bs-5925R
    英文名稱(chēng) MAS1 Rabbit pAb
    中文名稱(chēng) MAS1癌基因抗體
    別    名 Mas-related G protein-coupled receptor A; MAS1 oncogene; MAS; MGRA; MAS_HUMAN.  
    Specific References  (2)     |     bs-5925R has been referenced in 2 publications.
    [IF=3.743] Chen Q et al. Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway. Biomed Pharmacother. 2019 Jul;115:108971.  WB ;  Mouse&Human.  
    [IF=0.181] Zhang H et al. Effects of the combination of Herba Epimedii and Semen Plentaginis on the aortic ACE2/Angiotensin-(1-7)/Mas receptor axis and blood pressure in spontaneously hypertensive rats. Int J Clin Exp Med. 2019;12(4):3376-3386  IHC-P&WB ;  Rat.  
    研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉導  生長(cháng)因子和激素  細胞周期蛋白  轉錄調節因子  細胞表面分子  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,GuineaPig,Horse)
    產(chǎn)品應用 Flow-Cyt=1ug/Test
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 37 kDa
    檢測分子量
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human MAS1: 51-150/325 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP binding proteins and share a conserved structural motif, which is described as a '7 transmembrane segment' following the prediction that these hydrophobic segments form membrane spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth regulating pathway to bring about oncogenic effects.

    Function:
    Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

    Subunit:
    Interacts with AGTR1 (Probable).

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein.

    Similarity:
    Belongs to the G-protein coupled receptor 1 family.

    SWISS:
    P04201

    Gene ID:
    4142

    Database links:

    Entrez Gene: 4142 Human

    Omim: 165180 Human

    SwissProt: P04201 Human

    Unigene: 99900 Human



    產(chǎn)品圖片
    Blank control: HepG2. Primary Antibody (green line): Rabbit Anti-MAS1 antibody (bs- 5925R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-FITC Dilution: 1μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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