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    Cyclin A1 Rabbit pAb (bs-5739R)  
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    50ul/1180.00元
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    產(chǎn)品編號 bs-5739R
    英文名稱(chēng) Cyclin A1 Rabbit pAb
    中文名稱(chēng) 周期素A1蛋白抗體
    別    名 CCN A1; Cyclin-A1; CCNA 1; CCNA1; CyclinA1; MGC132235; MGC159139.  
    Specific References  (12)     |     bs-5739R has been referenced in 12 publications.
    [IF=11.205] Cong Lan. et al. Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction. EBIOMEDICINE. 2022 Aug;82:104139  WB ;  Rat.  
    [IF=7.65] Zhang L et al. Silica Nanoparticles exacerbates reproductive toxicity development in high-fat diet-treated Wistar rats. J Hazard Mater.?2019 Oct 1:121361.  WB ;  Rat.  
    [IF=5.652] Haijun Sun. et al. WD Repeat Domain 43 promotes malignant progression of non-small cell lung cancer by regulating CDK2. INT J BIOCHEM CELL B. 2022 Aug;:106293  WB ;  Human.  
    [IF=5.01] Ghate, N. B., et al. "Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio." Cell Death Discovery 2 (2016).  WB ;  
    [IF=3.73] Ghate, Nikhil Baban, et al. "An Antioxidant Extract of Tropical Lichen, Parmotrema reticulatum, Induces Cell Cycle Arrest and Apoptosis in Breast Carcinoma Cell Line MCF-7." PLOS ONE 8.12 (2013): e82293.  WB ;  Human.  
    [IF=2.737] A K Shendgeet al. A natural flavonoid, apigenin isolated from Clerodendrum viscosum leaves, induces G2/M phase cell cycle arrest and apoptosis in MCF-7 cells through the regulation of p53 and caspase-cascade pathway. Clin Transl Oncol . 2020 Jul 27.  WB ;  Human.  
    [IF=2.718] Wen Li. et al. Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis. J ANIM PHYSIOL AN N. 2022 Aug;:  WB ;  Mouse.  
    [IF=2.559] Hao?X et al. Reverse the down regulation of miR-92b-3p by hypoxia can suppress the proliferation of pulmonary artery smooth muscle cells by targeting USP28. Biochem Biophys Res Commun. 2018 Sep 18;503(4):3064-3077.   WB ;  Rat.  
    [IF=2.22] Wang, Chengke, and Zhenxin Wang. "Studying the relationship between cell cycle and Alzheimer’s disease by gold nanoparticle probes." Analytical Biochemistry (2015).  ELISA ;  Human.  
    [IF=2.16] Zhang, Jin, et al. "Silica nanoparticles induce start inhibition of meiosis and cell cycle arrest via down-regulating meiotic relevant factors." Toxicology Research (2016).  WB ;  Mouse.  
    [IF=1.84] Zhao, Yong, et al. "Inhibition of peripubertal sheep mammary gland development by cysteamine through reducing progesterone and growth factor production." Theriogenology (2016).  WB ;  Sheep.  
    [IF=1.402] Anil Khushalrao Shendge. et al. The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells. Mol Biol Rep. 2021 Jan;48(1):539-549  WB ;  
    研究領(lǐng)域 腫瘤  免疫學(xué)  細胞周期蛋白  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Mouse,Rat (predicted: Human,Rabbit,Pig,Cow,Dog,Horse)
    產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 51 kDa
    檢測分子量
    細胞定位 細胞核 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin A1: 211-310/465 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 Cyclin A1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A1 is expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. It binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Cyclin A1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.

    Function:
    Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.

    Subcellular Location:
    Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER.

    Similarity:
    Belongs to the cyclin family. Cyclin AB subfamily.

    SWISS:
    P78396

    Gene ID:
    8900

    Database links:

    Entrez Gene: 8900 Human

    Entrez Gene: 12427 Mouse

    Omim: 604036 Human

    SwissProt: P78396 Human

    SwissProt: Q61456 Mouse

    Unigene: 417050 Human

    Unigene: 4815 Mouse



    產(chǎn)品圖片
    Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Cyclin A1) Polyclonal Antibody, Unconjugated (bs-5739R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    Tissue/cell: rat ovary tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Cyclin A1 Polyclonal Antibody, Unconjugated(bs-5739R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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