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    Cdc25B Rabbit pAb (bs-4094R)  
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    產(chǎn)品編號 bs-4094R
    英文名稱(chēng) Cdc25B Rabbit pAb
    中文名稱(chēng) 細胞分裂周期蛋白25B抗體
    別    名 Cdc 25B; Cdc25b; Cdc-25b; CDC25HU2; Cdc25m2; Cell division cycle 25 homolog B; Cell division cycle 25B; Cell division cycle 25B isoform 1; Cell division cycle 25B isoform 2; Cell division cycle 25B isoform 3; Cell division cycle 25B isoform 4; Cell division cycle 25B isoform 5; Dual specificity phosphatase Cdc25B; M phase inducer phosphatase 2; M-phase inducer phosphatase 2; MPIP2_HUMAN.  
    研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  細胞周期蛋白  激酶和磷酸酶  表觀(guān)遺傳學(xué)  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Dog)
    產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 65 kDa
    檢測分子量
    細胞定位 細胞漿 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Cdc25B: 501-580/580 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008].

    Function:
    Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

    Subunit:
    Interacts with MAPK14 and 14-3-3 proteins.

    Subcellular Location:
    Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole.

    Post-translational modifications:
    Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.

    Similarity:
    Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.

    SWISS:
    P30305

    Gene ID:
    994

    Database links:

    Entrez Gene: 994 Human

    Entrez Gene: 12531 Mouse

    Entrez Gene: 171103 Rat

    Omim: 116949 Human

    SwissProt: P30305 Human

    SwissProt: P30306 Mouse

    SwissProt: P48966 Rat

    Unigene: 153752 Human

    Unigene: 38444 Mouse

    Unigene: 11312 Rat



    產(chǎn)品圖片
    Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Mouse NIH/3T3 cell lysates Lane 3: Mouse Sp2/0 cell lysates Lane 4: Human A549 cell lysates Lane 5: Human Daudi cell lysates Lane 6: Human K562 cell lysates Primary: Anti-Cdc25B (bs-4094R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kDa Observed band size: 60 kDa
    Sample: Spleen (Mouse) Lysate at 40 ug Primary: Anti-Cdc25B (bs-4094R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD
    Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Cdc25B ) Polyclonal Antibody, Unconjugated (bs-4094R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.
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