| 產(chǎn)品編號 | bs-5044R |
| 英文名稱(chēng) | COL4A3BP Rabbit pAb |
| 中文名稱(chēng) | IV型膠原α3結合蛋白抗體 |
| 別 名 | alpha 3 type IV collagen binding protein; C43BP_HUMAN; Ceramide transfer protein; Ceramide transporter; CERT; Cert protein; CERTL; col4a3bp; Collagen type IV alpha 3(Goodpasture antigen) binding protein; Collagen type IV alpha 3 binding protein; Collagen type IV alpha-3-binding protein; FLJ20597; Goodpasture antigen binding protein; Goodpasture antigen-binding protein; GPBP; hCERT; Lipid transfer protein CERTL; Procollagen type IV alpha 3(Goodpasture antigen) binding protein; StAR related lipid transfer(START) domain containing 11; StAR related lipid transfer protein 11; StAR-related lipid transfer protein 11; StARD 11; StARD11; START domain containing 11; START domain containing protein 11; START domain-containing protein 11. |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 信號轉導 細胞周期蛋白 激酶和磷酸酶 結合蛋白 細胞骨架 脂蛋白 細胞外基質(zhì) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | Rat (predicted: Human,Mouse,Rabbit,Cow) |
| 產(chǎn)品應用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 71 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COL4A3BP: 551-624/624 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
COL4A3BP is a kinase that specifically phosphorylates the N terminal region of the non collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Two transcripts exist for this gene. Function: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. Subunit: Interacts with COL4A3. Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA. Subcellular Location: Cytoplasm. Golgi apparatus. Endoplasmic reticulum. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Similarity: Contains 1 PH domain. Contains 1 START domain. SWISS: Q9Y5P4 Gene ID: 10087 Database links: Entrez Gene: 10087 Human Entrez Gene: 68018 Mouse Omim: 604677 Human SwissProt: Q9Y5P4 Human SwissProt: Q9EQG9 Mouse Unigene: 270437 Human Unigene: 24125 Mouse Unigene: 105704 Rat COL4A3BP蛋白目前，主要用于Goodpasture綜合征等方面的研究。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (COL4A3BP) Polyclonal Antibody, Unconjugated (bs-5044R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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