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    GRM2+GRM4 Rabbit pAb (bs-2139R)  
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    產(chǎn)品編號 bs-2139R
    英文名稱(chēng) GRM2+GRM4 Rabbit pAb
    中文名稱(chēng) 促代謝型谷氨酸受體2+4抗體
    別    名 Metabotropic Glutamate Receptor 2+4; GRM2+GRM4; GRM2+GRM4; GRM2/GRM4; GPRC1B; GPRC1D; GRM2; GRM4; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 4; mGluR2; mGluR4; GRM2_HUMAN; GRM4_HUMAN.  
    研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  信號轉導  G蛋白偶聯(lián)受體  G蛋白信號  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Human (predicted: Mouse,Rat)
    產(chǎn)品應用 WB=1:500-2000
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 102 kDa
    檢測分子量
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human GRM2+GRM4: 31-130/872 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

    Function:
    Receptor for glutamate. The activity of this receptor is mediated by a G protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

    Subcellular Location:
    Cell Membrane

    SWISS:
    Q14416

    Gene ID:
    2912

    Database links:

    Entrez Gene: 2912 Human

    Entrez Gene: 2914 Human

    Entrez Gene: 24415 Rat

    Entrez Gene: 24417 Rat

    Omim: 604099 Human

    Omim: 604100 Human

    SwissProt: Q14416 Human

    SwissProt: Q14833 Human

    SwissProt: P31421 Rat

    SwissProt: P31423 Rat



    產(chǎn)品圖片
    Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human HeLa cell lysates Lane 3: Human K562 cell lysates Lane 4: Human SH-SY5Y cell lysates Primary: Anti-GRM2+GRM4 (bs-2139R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 102 kDa Observed band size: 120 kDa
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